Wednesday, February 27, 2013

AP Source: NCAA found $170K in Shapiro benefits

(AP) ? The NCAA is alleging that former Miami booster Nevin Shapiro was responsible for providing about $170,000 in impermissible benefits to Hurricanes athletes, recruits, coaches and others between 2002 and 2010.

Shapiro allegedly spent more than half that amount ? at least $90,000 ? in an effort to get NFL players Vince Wilfork and Antrel Rolle to sign with a sports agency he was involved with, said the person, who spoke to The Associated Press Wednesday on condition of anonymity because neither Miami nor the NCAA has publicly released the allegations.

Also included in the allegations: That Shapiro spent at least another $56,000 on "meals, entertainment, clothing, jewelry, travel, lodging and cash" on football players, recruits and others. The NCAA alleged that Shapiro spent that on 72 then-players, three recruits and 12 "friends and family members" of those either on the team or being recruited by the school.

Virtually all of the Hurricane players listed as receiving some sort of extra benefit from Shapiro left the program several years ago.

The figures that the NCAA's enforcement staff cited in the notice of allegations add up to a significantly lower total than what Shapiro told Yahoo Sports in 2011, when he estimated his extra-benefit spending spree as going into the "millions of dollars."

If true, the NCAA only listed a sliver of that in the allegations. The figures that were sent to Miami also were described as "approximate total values."

The NCAA said Shapiro also provided extra benefits in the forms of impermissible supplemental compensation to at least three former Miami assistant coaches, along with travel benefits and other items.

Miami received its notice of allegations, ones that included a lack of institutional control for failing to properly monitor Shapiro's activities as a booster, last week. It also includes charges that three former assistant coaches broke what's known as the NCAA's Rule 10.1 ? governing ethical conduct ? by misleading the investigation. Two of those former assistants have asked that their cases be thrown out because of problems the NCAA acknowledged with the way it conducted the probe.

The NCAA's Committee on Infractions wants to hear the case in June.

The Hurricanes have already self-imposed several sanctions, including sitting out two bowl games and a conference football championship game. Miami President Donna Shalala said on two occasions last week that she believes those punishments should be enough, and on Wednesday, the Hurricanes' athletic director echoed those sentiments.

"I would say I agree with everything that was in the two statements by President Shalala," Blake James, Miami's athletic director, told The AP. "I think she was right on in her comments and was very reflective of the general feel of our institution and those involved in this case."

Shapiro is serving a 20-year prison term for masterminding a $930 million Ponzi scheme.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-02-27-Miami-NCAA-Investigation/id-a26e1f8c765b4ee68df19e4b1131041b

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Source: http://colnotion.com/index.php?do=/blog/162201/military-surplus-assault-vest-combat-arms-arm/

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Tuesday, February 26, 2013

Unlimited source of human kidney cells created

Feb. 21, 2013 ? Researchers at the Institute of Bioengineering and Nanotechnology (IBN) have successfully generated human kidney cells from human embryonic stem cells in vitro1. Specifically, they produced the renal cells under artificial conditions in the lab without using animals or organs. This has not been possible until now.

According to IBN Executive Director, Professor Jackie Y. Ying, "This discovery has wide-reaching implications for in vitro toxicology, drug screening, disease models and regenerative medicine. In particular, we are interested in applying our technology to develop predictive in vitro drug testing and renal toxicity models as alternatives to animal testing."

IBN Team Leader and Principal Research Scientist Dr Daniele Zink elaborated, "The kidney is a major target organ for drug-induced toxic effects. Therefore, it is important for pharmaceutical companies to find out early in the development phase whether their drugs would cause nephrotoxicity in humans. However, animal models are of limited predictability, and there is currently no regulatory accepted in vitro assay based on renal cells to predict nephrotoxic effects. A major problem is the lack of suitable renal cells, which may now be resolved through our discovery."

At present, human kidney cells are extracted directly from human kidney samples. However, this method is not efficient because such samples are limited, and the extracted cells die after a few cell divisions in the petri dish. Also, cells obtained from different samples would display variable features, depending on age, gender, health status and other conditions of the donor. Therefore, cells that have been isolated from human samples are of limited suitability for research and applications in industry and translational medicine, which require large cell numbers.

An alternative approach is to use human renal cell lines that have been rendered immortal, i.e. they can be reproduced indefinitely in the lab. However, such cells may not be used in many applications due to safety issues, and their functional features have usually been changed so profoundly that they may no longer be useful toward predicting cell behavior in the human body.

IBN's technique, on the other hand, enables human embryonic stem cells to differentiate into renal proximal tubular-like cells. This particular kidney cell type plays an important role in kidney disease-related processes and drug clearance. Results showed that the renal proximal tubular-like cells generated by IBN were similar to the renal proximal tubular cells isolated from fresh human kidney samples. For example, they displayed very similar gene and protein expression patterns. Also, since human embryonic stem cells may grow indefinitely in cell culture, the IBN researchers have discovered a potentially unlimited source of human kidney cells.

"We are currently adapting our approach to use induced pluripotent stem cells as the source," shared Dr Karthikeyan Narayanan, IBN Senior Research Scientist. "We are also planning to modify our protocol in order to generate other renal cell types from stem cells."

The IBN researchers have tested the renal cells they generated in in vitro nephrotoxicology models developed by the Institute, and have obtained very promising test results. They welcome industry partners to collaborate with IBN on commercializing this technology.

IBN has recently received a grant from A*STAR's Joint Council Office Development Program to further develop predictive in vitro models for liver- and kidney-specific toxicity. This project will be conducted in collaboration with the Experimental Therapeutics Centre, the Bioinformatics Institute and the National University Health System.

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Story Source:

The above story is reprinted from materials provided by Agency for Science, Technology and Research (A*STAR), Singapore.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Karthikeyan Narayanan, Karl M Schumacher, Farah Tasnim, Karthikeyan Kandasamy, Annegret Schumacher, Ming Ni, Shujun Gao, Began Gopalan, Daniele Zink, Jackie Y Ying. Human embryonic stem cells differentiate into functional renal proximal tubular?like cells. Kidney International, 2013; DOI: 10.1038/ki.2012.442

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/jNE4WDo0aas/130226092142.htm

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LG buys WebOS from HP to use in smart TVs

Palm's ill-fated WebOS has been bought again, this time by Korean electronics giant LG, ostensibly to support the company's development of smart TVs. But don't expect a Palm TV ? the once-admired OS is more likely to just fade into the background.

The purchase includes the OS itself and most of its critical components, including patents (although not its meager app catalog). Fans of the OS will be happy to hear that the open source projects started by HP will continue as before, albeit under the "stewardship" of LG. Still have a WebOS handset? HP will continue to provide support.

The financial terms of the deal were not announced, suggesting the purchase price was not particularly high; HP would probably like to avoid highlighting a poor return on their investment in Palm. Regardless, neither party believed the transaction would affect either of their stock prices.

HP acquired Palm for $1.2 billion three years ago ? a short time in the business world, but an eternity in software and technology. Palm's WebOS, widely hailed at its 2009 launch as an innovative and powerful alternative to both iOS and Android, was slated to power a new generation of HP consumer devices, none of which ever materialized.

LG states that WebOS was purchased to augment their next wave of smart TVs, and certainly the intuitive interface and patents in Palm's swan song could help with that. The world may be eagerly awaiting an Apple TV set, but in the meantime existing companies are fighting tooth and nail for space in the living room, and a novel and user-friendly OS (as LG seems to be planning) could be a coup.

But a few ideas and interface patents are likely all that can be salvaged from WebOS at this point for LG's purposes. Anyone who's hoping for a second (or third) coming of WebOS in the form of a smart TV will likely be disappointed.

Devin Coldewey is a contributing writer for NBC News Digital. His personal website is coldewey.cc.

Source: http://www.nbcnews.com/technology/gadgetbox/lg-buys-webos-hp-use-smart-tvs-1C8540546

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Investors face another Washington deadline

NEW YORK (Reuters) - Investors face another Washington-imposed deadline on government spending cuts next week, but it's not generating the same level of fear as two months ago when the "fiscal cliff" loomed large.

Investors in sectors most likely to be affected by the cuts, like defense, seem untroubled that the budget talks could send stocks tumbling.

Talks on the U.S. budget crisis began again this week leading up to the March 1 deadline for the so-called sequestration when $85 billion in automatic federal spending cuts are scheduled to take effect.

"It's at this point a political hot button in Washington but a very low level investor concern," said Fred Dickson, chief market strategist at D.A. Davidson & Co. in Lake Oswego, Oregon. The fight pits President Barack Obama and fellow Democrats against congressional Republicans.

Stocks rallied in early January after a compromise temporarily avoided the fiscal cliff, and the Standard & Poor's 500 index <.spx> has risen 6.3 percent since the start of the year.

But the benchmark index lost steam this week, posting its first week of losses since the start of the year. Minutes on Wednesday from the last Federal Reserve meeting, which suggested the central bank may slow or stop its stimulus policy sooner than expected, provided the catalyst.

National elections in Italy on Sunday and Monday could also add to investor concern. Most investors expect a government headed by Pier Luigi Bersani to win and continue with reforms to tackle Italy's debt problems. However, a resurgence by former leader Silvio Berlusconi has raised doubts.

"Europe has been in the last six months less of a topic for the stock market, but the problems haven't gone away. This may bring back investor attention to that," said Kim Forrest, senior equity research analyst at Fort Pitt Capital Group in Pittsburgh.

OPTIONS BULLS TARGET GAINS

The spending cuts, if they go ahead, could hit the defense industry particularly hard.

Yet in the options market, bulls were targeting gains in Lockheed Martin Corp , the Pentagon's biggest supplier.

Calls on the stock far outpaced puts, suggesting that many investors anticipate the stock to move higher. Overall options volume on the stock was 2.8 times the daily average with 17,000 calls and 3,360 puts traded, according to options analytics firm Trade Alert.

"The upside call buying in Lockheed solidifies the idea that option investors are not pricing in a lot of downside risk in most defense stocks from the likely impact of sequestration," said Jared Woodard, a founder of research and advisory firm condoroptions.com in Forest, Virginia.

The stock ended up 0.6 percent at $88.12 on Friday.

If lawmakers fail to reach an agreement on reducing the U.S. budget deficit in the next few days, a sequester would include significant cuts in defense spending. Companies such as General Dynamics Corp and Smith & Wesson Holding Corp could be affected.

General Dynamics Corp shares rose 1.2 percent to $67.32 and Smith & Wesson added 4.6 percent to $9.18 on Friday.

EYES ON GDP DATA, APPLE

The latest data on fourth-quarter U.S. gross domestic product is expected on Thursday, and some analysts predict an upward revision following trade data that showed America's deficit shrank in December to its narrowest in nearly three years.

U.S. GDP unexpectedly contracted in the fourth quarter, according to an earlier government estimate, but analysts said there was no reason for panic, given that consumer spending and business investment picked up.

Investors will be looking for any hints of changes in the Fed's policy of monetary easing when Fed Chairman Ben Bernake speaks before congressional committees on Tuesday and Wednesday.

Shares of Apple will be watched closely next week when the company's annual stockholders' meeting is held.

On Friday, a U.S. judge handed outspoken hedge fund manager David Einhorn a victory in his battle with the iPhone maker, blocking the company from moving forward with a shareholder vote on a controversial proposal to limit the company's ability to issue preferred stock.

(Additional reporting by Doris Frankel; Editing by Kenneth Barry)

Source: http://news.yahoo.com/investors-face-another-washington-deadline-142758934--finance.html

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A roundup of the best photos of the day

It began as a seemingly awkward Jack Nicholson introduction of the very long list on nominees, but the Best Picture denouement?at a very long Oscars ceremony on Sunday turned into a surprise appearance by Michelle Obama, via satellite from the Governors' Ball in Washington, D.C.?where earlier she had sat next to Chris Christie?to introduce and announce the winner,?Argo.?

Source: http://news.yahoo.com/photos/photos-of-the-day-1340925511-slideshow/

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Koop, who transformed surgeon general post, dies

FILE - In this Feb. 12, 2002 file photo, former U.S. Surgeon General, Dr. C. Everett Koop testifies in Concord, N.H. Koop, who raised the profile of the surgeon general by riveting America's attention on the then-emerging disease known as AIDS and by railing against smoking, has died in New Hampshire at age 96. (AP Photo/Jim Cole, File)

FILE - In this Feb. 12, 2002 file photo, former U.S. Surgeon General, Dr. C. Everett Koop testifies in Concord, N.H. Koop, who raised the profile of the surgeon general by riveting America's attention on the then-emerging disease known as AIDS and by railing against smoking, has died in New Hampshire at age 96. (AP Photo/Jim Cole, File)

FILE - In this May 12, 1997 file photo, former Surgeon General Dr. C. Everett Koop discusses the proposed increase of the New Hampshire cigarette tax at the governor's office in the Statehouse in Concord, H.H. Koop, who raised the profile of the surgeon general by riveting America's attention on the then-emerging disease known as AIDS and by railing against smoking, died Monday, Feb. 25, 2013, in Hanover, N.H. He was 96. (AP Photo/Andrew Sullivan, File)

FILE - In this Oct. 1, 1993 file photo, former Surgeon Genera C. Everett Koop, left, sits with then-first lady Hillary Rodham Clinton during a meeting with more than 100 prominent doctors in the White House in Washington. Koop, who raised the profile of the surgeon general by riveting America's attention on the then-emerging disease known as AIDS and by railing against smoking, died Monday, Feb. 25, 2013, in Hanover, N.H. He was 96. (AP Photo, File)

FILE - In this Aug. 29, 1991 file photo, former Surgeon General C. Everett Koop speaks in Washington during a conference for preventing transmission of Human Immunodeficiency Virus and Hepatitis B Virus to patients during procedures by medical personal. Koop, who raised the profile of the surgeon general by riveting America's attention on the then-emerging disease known as AIDS and by railing against smoking, died Monday, Feb. 25, 2013, in Hanover, N.H. He was 96. (AP Photo/Barry Thumma, File)

FILE - In this Sept. 14, 1988 file photo, U.S. Surgeon General C. Everett Koop speaks in Philadelphia. Koop, who raised the profile of the surgeon general by riveting America's attention on the then-emerging disease known as AIDS and by railing against smoking, died Monday, Feb. 25, 2013, in Hanover, N.H. He was 96. (AP Photo/Robert J. Gurecki, File)

With his striking beard and starched uniform, former Surgeon General C. Everett Koop became one of the most recognizable figures of the Reagan era ? and one of the most unexpectedly enduring.

His nomination in 1981 met a wall of opposition from women's groups and liberal politicians, who complained President Ronald Reagan selected Koop, a pediatric surgeon and evangelical Christian from Philadelphia, only because of his conservative views, especially his staunch opposition to abortion.

Soon, though, he was a hero to AIDS activists, who chanted "Koop, Koop" at his appearances but booed other officials. And when he left his post in 1989, he left behind a landscape where AIDS was a top research and educational priority, smoking was considered a public health hazard, and access to abortion remained largely intact.

Koop, who turned his once-obscure post into a bully pulpit for seven years during the Reagan and George H.W. Bush administrations and who surprised both ends of the political spectrum by setting aside his conservative personal views on issues such as homosexuality and abortion to keep his focus sharply medical, died Monday at his home in Hanover, N.H. He was 96.

An assistant at Koop's Dartmouth College institute, Susan Wills, confirmed his death but didn't disclose its cause.

Dr. Richard Carmona, who served as surgeon general a decade ago under President George W. Bush, said Koop was a mentor to him and preached the importance of staying true to the science even if it made politicians uncomfortable.

"He set the bar high for all who followed in his footsteps," Carmona said.

Although the surgeon general has no real authority to set government policy, Koop described himself as "the health conscience of the country" and said modestly just before leaving his post that "my only influence was through moral suasion."

A former pipe smoker, Koop carried out a crusade to end smoking in the United States; his goal had been to do so by 2000. He said cigarettes were as addictive as heroin and cocaine. And he shocked his conservative supporters when he endorsed condoms and sex education to stop the spread of AIDS.

Chris Collins, a vice president of amFAR, the Foundation for AIDS Research, said many people don't realize what an important role Koop played in the beginning of the AIDS epidemic.

"At the time, he really changed the national conversation, and he showed real courage in pursuing the duties of his job," Collins said.

Even after leaving office, Koop continued to promote public health causes, from preventing childhood accidents to better training for doctors.

"I will use the written word, the spoken word and whatever I can in the electronic media to deliver health messages to this country as long as people will listen," he promised.

In 1996, he rapped Republican presidential hopeful Bob Dole for suggesting that tobacco was not invariably addictive, saying Dole's comments "either exposed his abysmal lack of knowledge of nicotine addiction or his blind support of the tobacco industry."

Although Koop eventually won wide respect with his blend of old-fashioned values, pragmatism and empathy, his nomination met staunch opposition.

Foes noted that Koop traveled the country in 1979 and 1980 giving speeches that predicted a progression "from liberalized abortion to infanticide to passive euthanasia to active euthanasia, indeed to the very beginnings of the political climate that led to Auschwitz, Dachau and Belsen."

But Koop, a devout Presbyterian, was confirmed after he told a Senate panel he would not use the surgeon general's post to promote his religious ideology. He kept his word.

In 1986, he issued a frank report on AIDS, urging the use of condoms for "safe sex" and advocating sex education as early as third grade.

He also maneuvered around uncooperative Reagan administration officials in 1988 to send an educational AIDS pamphlet to more than 100 million U.S. households, the largest public health mailing ever.

Koop personally opposed homosexuality and believed sex should be saved for marriage. But he insisted that Americans, especially young people, must not die because they were deprived of explicit information about how HIV was transmitted.

Koop further angered conservatives by refusing to issue a report requested by the Reagan White House, saying he could not find enough scientific evidence to determine whether abortion has harmful psychological effects on women.

Koop maintained his personal opposition to abortion, however. After he left office, he told medical students it violated their Hippocratic oath. In 2009, he wrote to Senate Majority Leader Harry Reid, urging that health care legislation include a provision to ensure doctors and medical students would not be forced to perform abortions. The letter briefly set off a security scare because it was hand delivered.

Koop served as chairman of the National Safe Kids Campaign and as an adviser to President Bill Clinton's health care reform plan.

At a congressional hearing in 2007, Koop spoke about political pressure on the surgeon general post. He said Reagan was pressed to fire him every day, but Reagan would not interfere.

Koop, worried that medicine had lost old-fashioned caring and personal relationships between doctors and patients, opened his institute at Dartmouth to teach medical students basic values and ethics. He also was a part-owner of a short-lived venture, drkoop.com, to provide consumer health care information via the Internet.

Koop was born in the New York City borough of Brooklyn, the only son of a Manhattan banker and the nephew of a doctor. He said by age 5 he knew he wanted to be a surgeon and at age 13 he practiced his skills on neighborhood cats.

He attended Dartmouth, where he received the nickname Chick, short for "chicken Koop." It stuck for life.

Koop received his medical degree at Cornell Medical College, choosing pediatric surgery because so few surgeons practiced it.

In 1938, he married Elizabeth Flanagan, the daughter of a Connecticut doctor. They had four children, one of whom died in a mountain climbing accident when he was 20.

Koop was appointed surgeon-in-chief at Children's Hospital in Philadelphia and served as a professor at the University of Pennsylvania School of Medicine.

He pioneered surgery on newborns and successfully separated three sets of conjoined twins. He won national acclaim by reconstructing the chest of a baby born with the heart outside the body.

Although raised as a Baptist, he was drawn to a Presbyterian church near the hospital, where he developed an abiding faith. He began praying at the bedside of his young patients ? ignoring the snickers of some of his colleagues.

Koop's wife died in 2007, and he married Cora Hogue in 2010.

He was by far the best-known surgeon general and for decades afterward was still a recognized personality.

"I was walking down the street with him one time" about five years ago, recalled Dr. George Wohlreich, director of the College of Physicians of Philadelphia, a medical society with which Koop had longstanding ties. "People were yelling out, 'There goes Dr. Koop!' You'd have thought he was a rock star."

___

Ring reported from Montpelier, Vt. Cass reported from Washington. AP Medical Writers Lauran Neergaard in Washington and Mike Stobbe in New York contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2013-02-25-Obit-Koop/id-f20d0c4172e540a0a168a37bef6d07ee

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